JACKSONVILLE, Fla. — Jameis Winston and the hurricane-displaced Saints looked right at home in northeast Florida against Green Bay with a 38-3 victory — no doubt to the delight of fans rebuilding homes and lives back in New Orleans.

Winston passed for five touchdowns, New Orleans intercepted reigning NFL MVP Aaron Rodgers twice, and the Saints kicked off the post-Drew Brees era with a strikingly dominant opening victory.

The game, originally scheduled for the Superdome, was moved as the New Orleans area continues to clean up wreckage left by Hurricane Ida, which struck southeast Louisiana as a Category 4 storm Aug. 29, 16 years to the day after Hurricane Katrina devastated the same region.

After canceling their final preseason game and practicing two weeks in the Dallas area, the Saints looked as sharp and inspired as any team with such distractions could have hoped.

Winston, who led the NFL with 30 interceptions in his last season as a starter with Tampa Bay in 2019, largely was judicious and accurate in going 14-of-20 passing for 148 yards without an interception.

Juwan Johnson, who came in with four career catches and was converted from receiver to a tight end this offseason, had two scores.

Green Bay fans seemed to outnumber Saints fans in a crowd announced at 35,242 for what officially was a Saints home game. But they left disappointed in a day that could not have gone much worse for Rodgers, who was pulled with almost 11 minutes left. He finished 15-of-28 passing for 133 yards and no touchdowns. He led one drive to a field goal at the end of the first half.

Chiefs 33, Browns 29

KANSAS CITY, Mo. — Patrick Mahomes threw for 337 yards and three touchdowns while running for another score, and the Chiefs came back from a dismal first half in a rematch of their divisional playoff game from January.

Tyreek Hill caught 11 passes for 197 yards and a touchdown, and Travis Kelce hauled in a pair of scoring catches, including the go-ahead score as the Chiefs finished off their rally from a 22-10 halftime deficit.

The Chiefs won their fifth straight against Cleveland, including their 22-17 playoff victory, and their 15th consecutive game in September. They also pushed Andy Reid within one win of reaching 100 with two franchises.

As for the Browns? They fell to 1-21 in season openers since returning to Cleveland in 1999, extending their NFL mark to 17 consecutive defeats. They haven’t won an opener on the road since the 1994 season.

Baker Mayfield threw for 321 yards, but he was picked off by Chiefs cornerback Mike Hughes with 1:09 left to end any hope of a comeback. Nick Chubb ran for 83 yards and two scores, and Kareem Hunt and Jarvis Landry also had touchdown runs.

Dolphins 17, Patriots 16

FOXBOROUGH, Mass. — Tua Tagovailoa threw a go-ahead touchdown pass to Jaylen Waddle in the third quarter and Xavien Howard recovered a fumble with New England driving in the fourth.

It was Miami’s second consecutive win against the Patriots. Tagovailoa also led the Dolphins to a victory in the second meeting between the teams last season.

Tagovailoa finished 16-of-27 passing for 202 yards, a touchdown and one interception, and also had a 3-yard scoring run to lead a revamped offense that kept the Patriots’ rebuilt defense guessing, mixing in no-huddle and empty backfield formations. DeVante Parker caught four passes for 81 yards.

Miami’s win spoiled the debut of New England’s Mac Jones, the first rookie quarterback to start for the Patriots since Drew Bledsoe in 1993. Jones was 29-of-39 for 281 yards and a touchdown. Damien Harris rushed 23 times for 100 yards, but had the costly fumble to end New England’s comeback hopes.

Steelers 23, Bills 16

ORCHARD PARK, N.Y. — Ben Roethlisberger and the Steelers’ new-look offense overcame a slow start, and Ulysees Gilbert returned a blocked punt 9 yards for a touchdown as Pittsburgh rallied.

Down 10-0, the Steelers scored on each of their first four possessions of the second half, with Roethlisberger putting Pittsburgh ahead for good by lobbing a 5-yard touchdown pass to Diontae Johnson in the left corner of the end zone.

The pass initially went off Johnson’s fingertips, but the receiver secured the ball before tumbling out of bounds 3:41 into the fourth quarter. The Steelers extended their lead to 20-10 some 90 seconds later with Miles Killebrew bursting up the middle to block Matt Haack’s punt, with Gilbert scooping up the loose ball and running it in untouched.

In opening his 18th — and perhaps final — season, Roethlisberger posted his 36th career fourth-quarter comeback to tie Drew Brees for third on the NFL list. He finished 18-of-32 passing for 188 yards and a touchdown.

Chris Boswell hit all three field-goal attempts, including a game-sealing 45-yarder with 2:42 remaining.

Cardinals 38, Titans 13

NASHVILLE, Tenn. — Kyler Murray threw four touchdown passes and had another score on a run, and linebacker Chandler Jones had a career-high five sacks.

Jones, who tied the franchise record, had three sacks in a first quarter so good LeBron James chimed in on social media for his defensive player of the year candidacy. Jones, who wants a new contract, also forced two fumbles the Cardinals turned into 14 points.

Murray tormented the Titans throwing for 289 yards with two touchdown passes apiece to All-Pro receiver DeAndre Hopkins and Christian Kirk. Murray’s best pass came came early in the third quarter off his back foot to Kirk on a beautiful floater Kirk simply ran under.

Arizona scored the first 17 points and moved the ball almost at will against Tennessee.

Rams 34, Bears 14

INGLEWOOD, Calif. — Matthew Stafford passed for 321 yards and three touchdowns in a dynamic debut with his new team, leading Los Angeles past Andy Dalton and the Bears.

Stafford found Van Jefferson for a 67-yard touchdown on his second pass for the Rams, who swung a blockbuster offseason trade to acquire the 13-year veteran quarterback from Detroit. Stafford then hit a wide-open Cooper Kupp for a 56-yard score to open the third quarter, and he found Robert Woods for a clinching score with 3:17 to play.

Coach Sean McVay improved to 5-0 in season openers with the Rams, who scored on six of Stafford’s first seven full drives in racking up 375 yards of offense, and Kupp finished with seven catches for 108 yards.

Dalton passed for 206 yards in his Bears debut, and rookie quarterback Justin Fields rushed for a 3-yard score in getting a handful of snaps in his NFL debut. David Montgomery rushed for 108 yards and a touchdown for the Bears, who dropped to 1-3 in season openers under coach Matt Nagy.

49ers 41, Lions 33

DETROIT — Dre Greenlaw returned an interception for a touchdown to help the 49ers score 17 points in two-plus minutes late in the first half.

San Francisco led 38-10 early in the fourth quarter and allowed Detroit to score 23 points in three-plus minutes to pull within eight points. But the Lions turned the ball over on downs at the San Francisco 24-yard line with 12 seconds left after getting it back on a fumble by Deebo Samuel.

For most of the game, the 49ers performed more like the Super Bowl-contending team they were two years ago than the 10-loss team they had last season when injuries took a major toll.

Meanwhile, it looked like the many changes the Lions made might be moot in coach Dan Campbell’s debut — until the comeback provided some hope.

San Francisco welcomed back Jimmy Garoppolo and George Kittle on offense and Nick Bosa on defense after each missed much of last season with injuries.

Garoppolo, who helped San Francisco win the 2019 NFC championship, is 23-8 in the regular season since being acquired from New England. Kittle had four receptions for 78 yards. Bosa had four tackles, including a drive-ending sack early in the fourth quarter.

Texans 37, Jaguars 21

HOUSTON — Tyrod Taylor threw for 291 yards and two touchdowns filling in for Deshaun Watson in a win against Trevor Lawrence and the mistake-prone Jaguars.

Taylor took over at quarterback for Houston with Watson’s future with the team uncertain after 22 women filed lawsuits alleging sexual assault or harassment after he requested a trade.

Expectations for the Texans were low entering this season with Watson out and star defensive end J.J. Watt gone to Arizona. But Taylor and Houston’s revamped running game were more than enough to handle a Jaguars team that didn’t look much better than it was last season — when it got just one win — despite the addition of top overall pick Lawrence.

It was a bumpy debut for Lawrence. He threw for 332 yards and three touchdowns but also tossed three interceptions, often overthrew open receivers and was the victim of several drops. It also was the NFL debut for Jaguars coach Urban Meyer, who lost the first season opener of his head coaching career after entering the game having won 17 straight as a college coach.

His streak was halted by another coach making his NFL head coaching debut in Houston’s David Culley, a 65-year-old who spent decades as an assistant in the league before being hired by the Texans.

Chargers 20, Washington 16

LANDOVER, Md. — Justin Herbert threw for 337 yards and a touchdown in an ugly Week 1 matchup full of turnovers and big penalties.

Herbert led scoring drives of 75, 76 and 68 yards, and a go-ahead touchdown pass to Mike Williams made up for his fumble into the end zone and red zone interception on consecutive possessions. The reigning AP offensive tookie of the year and the Chargers went 14-of-19 on third downs, wearing down Washington’s defense led by last year’s top defensive rookie, Chase Young.

The teams combined for 14 penalties for 151 yards and three giveaways.

Los Angeles also got a 3-yard scoring run from Austin Ekeler, who was listed as questionable with a hamstring injury. Ekeler finished with 57 yards on 15 carries and joined Danny Woodhead as the only undrafted players in the NFL’s common draft era with 10-plus rushing and 15-plus passing touchdowns.

Loud cheers erupted from the visiting locker room as the Chargers celebrated Brandon Staley winning his coaching debut.

Washington lost veteran starting quarterback Ryan Fitzpatrick to a right hip injury midway through the fourth quarter of his team debut

Eagles 32, Falcons 6

ATLANTA — Jalen Hurts threw three touchdown passes, the first of them to Heisman Trophy winner DeVonta Smith, and the Eagles made a winner of Nick Sirianni in his head coaching debut.

Firmly entrenched as the Eagles starter after Carson Wentz was traded, Hurts certainly looked the part with touchdown passes of 18 yards to Smith, 9 yards to Dallas Goedert and 23 yards to Jalen Reagor. Another Philadelphia rookie, fifth-round pick Kenneth Gainwell, scored his first touchdown as a pro with an 8-yard run late in the third quarter.

In an often sloppy matchup between rookie head coaches and the NFC’s two worst teams a year ago, the Eagles limited the Falcons to a pair of field goals and got more than enough production from a revamped offense with Hurts calling the shots. Hurts completed 27 of 35 passes for 264 yards and used his mobility to repeatedly neutralize Atlanta’s attempt to shake him up with a variety of blitzes. He rushed for 62 yards on seven carries.

Coming off a 4-12 season in which they fired each their coach and general manager, and an offseason that featured the trade of seven-time Pro Bowl receiver Julio Jones, Matt Ryan and the Falcons got off to a miserable start under new coach Arthur Smith.

Bengals 27, Vikings 24

CINCINNATI — Evan McPherson kicked a 33-yard field goal as time expired in overtime. The winning kick was set up by a gutsy call. On fourth-and-inches from the Cincinnati 48, Joe Burrow rolled out and hit tight end C.J. Uzomah in stride for a 32-yard gain and get McPherson well within his range. McPherson had a 53-yard field goal early in the fourth quarter.

Cincinnati’s Germaine Pratt recovered Dalvin Cook’s fumble to set up the winning drive. Minnesota challenged the ruling that Cook had fumbled, but it was upheld after a replay review.

Greg Joseph kicked a career-long 53-yard field goal as time ran out in the fourth quarter to tie the game for Minnesota, which had battled back from a 21-7 second-half deficit.

Burrow threw for 261 yards and two touchdowns in his return after major knee surgery nine months ago, and rookie Ja’Marr Chase had 101 yards on five receptions, including a 50-yard scoring pass from his former LSU teammate.

Kirk Cousins passed for 351 yards and two touchdowns to Adam Thielen for the Vikings.

Panthers 19, Jets 14

CHARLOTTE, N.C. — Sam Darnold threw for 279 yards and a touchdown and ran for another score against his former team. Darnold connected on a 57-yard touchdown pass with fellow ex-Jet Robby Anderson and took full advantage of a healthy Christian McCaffrey, who piled up 187 yards from scrimmage on 30 touches after missing 13 games last season with injuries.

Carolina’s defense brought the pressure on Jets rookie quarterback Zach Wilson, sacking the No. 2 pick in the NFL draft six times and intercepting him once. But Wilson kept battling and finished 20-of-37 passing for 258 yards with two touchdown passes to Corey Davis in his first career start.

The loss also spoiled the head coaching debut of Robert Saleh for the Jets.

Broncos 27, Giants 13

EAST RUTHERFORD, N.J. — Teddy Bridgewater threw two touchdowns in his first start for Denver as the Broncos dominated possession.

Acquired in the offseason from Carolina, Bridgewater completed 28 of 36 passes for 264 yards, sharing the ball with nine receivers. The 28-year-old quarterback hit Tim Patrick on a go-ahead 2-yard touchdown pass with eight seconds left in the half. Bridgewater eluded pressure and found tight end Albert Okwuegbunam on a 4-yard, fourth-down toss during a 16-play, 75-yard drive to open the second half, extending the lead to 17-7.

Melvin Gordon III added a late 70-yard scoring run and Brandon McManus kicked two field goals for the Broncos, who have had four consecutive losing seasons since their Super Bowl 50 title.

Daniel Jones threw a 37-yard touchdown pass play to Sterling Shepard for New York and ran for a 4-yard touchdown on the final play. The third-year quarterback finished 22-of-37 passing for 253 yards. He also lost a fumble in the red zone with the Giants trailing 20-7 in the third quarter.

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